Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy
نویسندگان
چکیده
منابع مشابه
Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy.
AIMS Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where they are translocated into the lysosomal lumen and degraded via the lysosome-associated membrane protein type 2A (LAMP-2A). Mutations in LAMP2 that inhibit autophagy result in Dan...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2013
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvt029